O‘pkaning sekretor hujayralarining gistokimyoviy o‘ziga xos xususiyatlari
Histochemical characteristics of secretory cells of the lung
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Abstract
The aim of this study was to identify new morphofunctional characteristics of secretory cells in rabbit lung tissue during postnatal ontogenesis. Lung tissue samples obtained from rabbits aged from 1 day to 180 days were used as the research material. The following histological methods were employed: staining with hematoxylin and eosin, staining by the Van Gieson method, and impregnation using the Foot method. Fresh frozen sections were subjected to histochemical examination to study alkaline phosphatase activity using the Gomori method.
The results showed that, unlike the cells of the pulmonary acini, secretory cells were characterized by the highest activity of alkaline phosphatase. Although moderate enzyme activity was detected in these cells during most observation periods, an increase in alkaline phosphatase activity was recorded on the 7th, 15th, and 30th days after birth. During these periods, the increased activity of alkaline phosphatase in secretory cells was associated with a complex correlation involving the stromal component of the pulmonary acini, its argyrophilic properties, and especially the development of its elastic framework.
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Блинова С. А. и др. Постнатальное развитие респираторного отдела легких //Проблемы биологии и медицины. – 2022. – №. 3. – С. 136.
Килесса В. В. и др. Медикаментозная индукция регенерации легких при их поражении COVID-19 инфекцией //Крымский терапевтический журнал. – 2021. – №. 2. – С. 34-38.
Пруткина Е. В., Сепп А. В., Цыбиков Н. Н. Особенности синтеза матриксной металлопротеиназы-9 в легких при развитии дистресс-синдрома в эксперименте //Acta Biomedica Scientifica. – 2013. – №. 1 (89). – С. 121-124.
Пруткина Е. В., Сепп А. В., Цыбиков Н. Н. Роль HSP-70 в патогенезе респираторного дистресс-синдрома на фоне гриппозной пневмонии //Acta Biomedica Scientifica. – 2013. – №. 2-1 (90). – С. 71-75.
Blinova S.A., Oripov F.S., Khotamova G.B., Yuldasheva N.B. Morphofunctional changes in the respiratory lung during postnatal development // Journal of environmental health research.-2022.-V.1, №1.- Р.3-6.
Capelli A. et al. Lung alkaline phosphatase as a marker of fibrosis in chronic interstitial disorders //American journal of respiratory and critical care medicine. – 1997. – Т. 155. – №. 1. – С. 249-253. DOI: https://doi.org/10.1164/ajrccm.155.1.9001320
Guillot L. et al. Alveolar epithelial cells: master regulators of lung homeostasis //The international journal of biochemistry & cell biology. – 2013. – Т. 45. – №. 11. – С. 2568-2573. DOI: https://doi.org/10.1016/j.biocel.2013.08.009
Parimon T. et al. Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis //International journal of molecular sciences. – 2020. – Т. 21. – №. 7. – С. 2269. DOI: https://doi.org/10.3390/ijms21072269
Ruaro B. et al. The history and mystery of alveolar epithelial type II cells: focus on their physiologic and pathologic role in lung //International journal of molecular sciences. – 2021. – Т. 22. – №. 5. – С. 2566. DOI: https://doi.org/10.3390/ijms22052566
Yao C. et al. Senescence of alveolar type 2 cells drives progressive pulmonary fibrosis //American journal of respiratory and critical care medicine. – 2021. – Т. 203. – №. 6. – С. 707-717. DOI: https://doi.org/10.1164/rccm.202004-1274OC