О возможности регуляции структуры G-квадруплексов методами радиационной технологии

On the possibility of regulating the structure of G-quadruplexes by radiation technology methods

Main Article Content

Ashirmetov Abdurashid Khamidovich
Iskandarova F.A.
Oksengendler B.L.
Turayeva N.N.

Abstract

The molecular structures and the electronic structure of G-quadruplexes in DNA and RNA are examined, and the scope of their functional action, as well as some areas in biology and medicine, is outlined. Radiation-technological Auger processes in such structures are described that can influence the electron-atomic structure of G-quadruplexes and regulate their functions in the desired direction.

Article Details

Section

Fundamental and Applied Microbiology

How to Cite

Ashirmetov Abdurashid Khamidovich, Iskandarova F.A., Oksengendler B.L., & Turayeva N.N. (2026). On the possibility of regulating the structure of G-quadruplexes by radiation technology methods. Partner Conferences of the International Scientific Journal Research Focus, 1(8), 54-57. https://doi.org/10.66073/ReFocus-Conf/3010009

References

Lyu K, Chow EY, Mou X et al. RNA G-quadruplexes (rG4s): genomics and biological functions. Nucleic Acids Res. 2021;49(10):5426-5450. doi: 10.1093/nar/gkab187. DOI: https://doi.org/10.1093/nar/gkab187

Fay M.M., Lyons S.M., Ivanov P. RNA G-quadruplexes in biology: principles and molecular mechanisms. J Mol Biol. 2017; 429(14): 2127–2147. doi:10.1016/j.jmb.2017.05.017. DOI: https://doi.org/10.1016/j.jmb.2017.05.017

Guo J.U., Bartel D.P. RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria. Science. 2016; 353:aaf5371. DOI: https://doi.org/10.1126/science.aaf5371

Broglia L., Canale C., Vandelli A. et al. Decoding the Structural Complexity of Viral RNAs with SHAPE to Guide Antiviral Therapeutics. Viruses. 2026;18(5):543. doi: 10.3390/v18050543 DOI: https://doi.org/10.3390/v18050543

Stoltenburg R., Krafcikova P., Viglasky V., Strehlitz B. G-quadruplex aptamer targeting protein a and its capability to detect Staphylococcus aureus demonstrated by ELONA. Sci. Rep. 2016;6:33812. doi: 10.1038/srep33812. DOI: https://doi.org/10.1038/srep33812

E. Parilis, L. Kishinevskiy, N. Turaev, Atomic collisions on solid Surfaces, Elsevier Sci. Publ., North. Holl. Amsterdam, London, New York, Tokyo, 1993

Oksengendler B.L., Ashirmetov A. Kh., Turaeva N.N. The features of Auger destruction in quasi-one-dimensional objects of inorganic and organic nature. Nuclear Instruments and Methods in Physics Research Section B. 2022. V. 512(4). P. 66. doi: 10.1016/j.nimb.2021.12.009 DOI: https://doi.org/10.1016/j.nimb.2021.12.009

Абрукина Ю.М., Оксенгендлер Б.Л. Локализованные электронные состояния в одномерной простой цепи с петлей. Письма в ЖЭТФ. 1994. 60(4): 258-261.