Catharanthus roseus dan ajratilgan endofit zamburug‘lar metabolitlarining sitotoksik xususiyatlari

Cytotoxic properties of metabolites of endophytic fungi isolated from Catharanthus roseus

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Published: 2026-10-30
DOI: https://doi.org/10.66073/ReFocus-Conf/3010048
Keywords:
Catharanthus roseus, endophytic fungi, Aspergillus sp. VR176L, Aspergillus terreus VR177L, cytotoxicity, Vinca alkaloids, HeLa, SRB assay

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Otayeva Zarina Murotovna
Institute of Microbiology of the Academy of Sciences of the Republic of Uzbekistan
Nasmetova Saodat Mamajanovna
Institute of Microbiology of the Academy of Sciences of the Republic of Uzbekistan
Norkoziyeva Ozoda
Institute of Microbiology of the Academy of Sciences of the Republic of Uzbekistan

Abstract

This study investigated the cytotoxic activity of extracts from the endophytic fungi Aspergillus terreus VR177L and Aspergillus sp. VR176L isolated from Catharanthus roseus (L.) G. Don. The cytotoxic activity of the extracts at a concentration of 100 μg/mL was evaluated using the SRB assay. The highest activity was observed for the Aspergillus sp. VR176L extract, which inhibited HeLa cell growth by 70.6 ± 2.5%. These results indicate the potential of this extract as a source of biologically active compounds and support further investigation.

Article Details

Issue

Vol. 1 No. 8 (2026): Status and Development Prospects of Fundamental and Applied Microbiology: The Viewpoint of Young Scientists

Section

Biotechnology, Molecular Biology and Bioinformatics
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Otayeva Zarina Murotovna, Nasmetova Saodat Mamajanovna, & Norkoziyeva Ozoda. (2026). Cytotoxic properties of metabolites of endophytic fungi isolated from Catharanthus roseus. Partner Conferences of the International Scientific Journal Research Focus, 1(8), 184-186. https://doi.org/10.66073/ReFocus-Conf/3010048

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