Выделение и скрининг природных изолятов дрожжей по способности к продукции L-аспарагиназы
Isolation of natural yeast isolates and their screening for L-asparaginase production
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In this study, 146 yeast isolates were obtained from various natural samples collected in the Republic of Uzbekistan. Of these, 70 isolates belonged to pigment-producing (red) yeasts, while 76 were non-pigment-producing yeasts. Primary screening using bromothymol blue revealed that 31 strains of pigment-producing yeasts exhibited the highest L-asparaginase-producing potential, whereas 4 strains of non-pigment-producing yeasts demonstrated the highest L-asparaginase activity.
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U. Managamuri, M. Vijayalakshmi, V.R.K. Ganduri, R.S. Babu, S. Poda, Optimization of culture conditions by response surface methodology and unstructured kinetic modeling for L-asparaginase production by Pseudonocardia endophytica VUK-10, J. Appl. Pharm. Sci. 7 (2017) 42-50. DOI: https://doi.org/10.7324/JAPS.2017.70106
Baral A, Gorkhali R, Basnet A, Koirala S, Bhattarai HK. Selection of the optimal L-asparaginase II against acute lymphoblastic leukemia: an in silico approach. JMIRx Med. 2021;2(3):e29844. https://doi.org/10.2196/29844 PMID: 37725538 DOI: https://doi.org/10.2196/29844
Radadiya A, Zhu W, Coricello A, Alcaro S, Richards NGJ. Improving the treatment of acute lymphoblastic leukemia. Biochemistry. 2020;59(35):3193–200. https://doi.org/10.1021/acs.biochem.0c00354 DOI: https://doi.org/10.1021/acs.biochem.0c00354
Nguyen HA, Su Y, Zhang JY, Antanasijevic A, Caffrey M, Schalk AM, et al. A novel l-asparaginase with low l-glutaminase coactivity is highly efficacious against both T- and B-cell acute lymphoblastic leukemias in vivo. Cancer Res. 2018;78(6):1549–60. https://doi.org/10.1158/0008-5472.CAN-17-2106 PMID: 29343523 DOI: https://doi.org/10.1158/0008-5472.CAN-17-2106
Fonseca MHG, Fiúza T da S, Morais SB de, Souza T de ACB de, Trevizani R. Circumventing the side effects of L-asparaginase. Biomed Pharmacother. 2021;139:111616. https://doi.org/10.1016/j.biopha.2021.111616 PMID: 33932739 DOI: https://doi.org/10.1016/j.biopha.2021.111616
Andrade KCR, Fernandes RA, Pinho DB, de Freitas MM, Filho EXF, Pessoa A, et al. Sequencing and characterization of an L-asparaginase gene from a new species of Penicillium section Citrina isolated from Cerrado. Sci Rep. 2021;11(1):17861. https://doi.org/10.1038/s41598-021-97316-1 PMID: 34504186 DOI: https://doi.org/10.1038/s41598-021-97316-1
Hayashi H, Makimoto A, Yuza Y. Treatment of pediatric acute lymphoblastic leukemia: a historical perspective. Cancers (Basel). 2024;16(4):723. https://doi.org/10.3390/cancers16040723 PMID: 38398113 DOI: https://doi.org/10.3390/cancers16040723
Pola M, Rajulapati SB, Potla Durthi C, Erva RR, Bhatia M. In silico modelling and molecular dynamics simulation studies on L-Asparaginase isolated from bacterial endophyte of Ocimum tenuiflorum. Enzyme Microb Technol. 2018;117:32–40. https://doi.org/10.1016/j.enzmictec.2018.06.005 PMID: 30037549 DOI: https://doi.org/10.1016/j.enzmictec.2018.06.005
El-Naggar NE-A, Hamouda RA, Elshafey N. Artificial intelligence-based optimization for extracellular L-glutaminase free L-asparaginase production by Streptomyces violaceoruber under solid state fermentation conditions. Sci Rep. 2024;14(1):29625. https://doi.org/10.1038/s41598-024-77867-9 PMID: 39609450 DOI: https://doi.org/10.1038/s41598-024-77867-9
S. Zuo, T. Zhang, B. Jiang, W. Mu, Reduction of acrylamide level through blanching with treatment by an extremely thermostable l-asparaginase during French fries processing, Extremophiles 19 (2015) 841-851. DOI: https://doi.org/10.1007/s00792-015-0763-0
M. Duval, S. Suciu, A. Ferster, X. Rialland, B. Nelken, P. Lutz, Y. Benoit, A. Robert, A.-M. Manel, E. Vilmer, J. Otten, N. Philippe, Comparison of Escherichia coli–asparaginase with Erwinia-asparaginase in the treatment of childhood lymphoid malignancies: results of a randomized European organisation for research and treatment of cancer—Children's leukemia group phase 3 trial, Blood 99 (2002) 2734-2739. DOI: https://doi.org/10.1182/blood.V99.8.2734