Lactiplantibacillus plantarum tarafidan ishlab chiqariladigan antibakterial va antifungal metabolitlar va ularning ta’sir mexanizmlari

Antibacterial and antifungal metabolites produced by Lactiplantibacillus plantarum and their mechanisms of action

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Published: 2026-10-30
DOI: https://doi.org/10.66073/ReFocus-Conf/3010063
Keywords:
Lactiplantibacillus plantarum, plantaricin, cyclic dipeptides, 3-phenyllactic acid, antibacterial metabolites, antifungal activity, biofilm inhibition

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Goziyeva Mohlaroy Shahobiddin kizi
Andijan State University named after Zahiriddin Muhammad Babur
Abdukarimova Gulchekhrakhon Asliddin kizi
Andijan State University named after Zahiriddin Muhammad Babur

Abstract

Based on a systematic review of scientific literature and genomic/metabolomic data, this study investigated the antibacterial and antifungal metabolites synthesized by the probiotic Lactiplantibacillus plantarum and their underlying modes of action. It is demonstrated that L. plantarum utilizes its pln operon clusters to produce class II plantaricins (PlnE/F, PlnJ/K), as well as cyclic dipeptides belonging to the diketopiperazine group [Cyclo(L-Phe–L-Pro)], 3-phenyllactic acid (PLA), and phenolic compounds. These metabolites are capable of disrupting pathogenic bacterial membranes, inhibiting biofilm-forming enzymes of methicillin-resistant Staphylococcus aureus (MRSA), and suppressing the growth of filamentous fungi (Aspergillus, Fusarium, Penicillium). The findings confirm the strong potential of using these metabolites as biopreservatives in the food industry and as biological agents against multidrug-resistant strains in medicine.

Article Details

Issue

Vol. 1 No. 8 (2026): Status and Development Prospects of Fundamental and Applied Microbiology: The Viewpoint of Young Scientists

Section

Probiotics, Food and Pharmaceutical Microbiology
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Goziyeva Mohlaroy Shahobiddin kizi, & Abdukarimova Gulchekhrakhon Asliddin kizi. (2026). Antibacterial and antifungal metabolites produced by Lactiplantibacillus plantarum and their mechanisms of action. Partner Conferences of the International Scientific Journal Research Focus, 1(8), 229-233. https://doi.org/10.66073/ReFocus-Conf/3010063

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