Aspergillus tubingensis S23 as a promising source of pharmaceutically important secondary metabolites

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Published: 2026-10-30
DOI: https://doi.org/10.66073/ReFocus-Conf/3010082
Keywords:
Aspergillus tubingensis, endophytic fungi, secondary metabolites, biosynthetic gene clusters, kojic acid, natural-product discovery

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Kholikova Mavjuda Jonizokovna
National University of Uzbekistan named after Mirzo Ulugbek
Khan Asifullah
Institute for Advanced Studies at New Uzbekistan University
Eshboev Farhod Bakir ugli
Institute for Advanced Studies at New Uzbekistan University

Abstract

The biosynthetic potential of Aspergillus tubingensis S23, an endophytic fungus isolated from the medicinal plant Eremostachys isochila, was evaluated through whole-genome sequencing and comparative genome mining. Molecular phylogeny and phylogenomics supported its identification as A. tubingensis. antiSMASH predicted 95 biosynthetic gene cluster (BGC) regions, including regions similar to characterized clusters associated with kojic acid, yanuthone D, clavaric acid, TAN-1612, nidulanin A, and burnettiene A. These results indicate substantial potential for genome-guided natural-product discovery, although the production and biological activities of the predicted compounds require experimental verification.

Article Details

Issue

Vol. 1 No. 8 (2026): Status and Development Prospects of Fundamental and Applied Microbiology: The Viewpoint of Young Scientists

Section

Probiotics, Food and Pharmaceutical Microbiology
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Kholikova Mavjuda Jonizokovna, Khan Asifullah, & Eshboev Farhod Bakir ugli. (2026). Aspergillus tubingensis S23 as a promising source of pharmaceutically important secondary metabolites. Partner Conferences of the International Scientific Journal Research Focus, 1(8), 285-288. https://doi.org/10.66073/ReFocus-Conf/3010082

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