Interrelationship between human papillomavirus (HPV) infection and disturbances of the cervical microbiocenosis
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The article analyses evidence published in 2011–2025 on the interrelationship between human papillomavirus (HPV) infection and disturbances of the cervical microbiocenosis. A Lactobacillus-depleted anaerobic community state type (CST IV) is associated with HPV persistence and with the severity of cervical intraepithelial neoplasia (CIN): its share rises from 10% in normal cytology to 40% in invasive cancer. Lactobacillus dominance is linked to more frequent regression of CIN2 (70.0% vs 42.1%). The expediency of combining HPV screening with assessment of the microbiocenosis is substantiated.
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