Onkogen viruslar va ularning bolalar onkologiyasidagi roli
Oncogenic viruses and their role in pediatric oncology
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Abstract
According to the World Health Organization, cancer is diagnosed in approximately 400,000 children and adolescents aged 0–19 years worldwide each year [1].
In modern oncology, the role of infectious agents, particularly oncogenic viruses, in carcinogenesis is increasingly being studied.
Viruses with a reliably established association with human cancer include Epstein–Barr virus (EBV), high-risk human papillomaviruses (HPV), hepatitis B and C viruses (HBV, HCV), human T-cell leukemia virus type 1 (HTLV-1), Kaposi sarcoma-associated herpesvirus (HHV-8/KSHV) and Merkel cell polyomavirus (MCPyV) [2, 3].
EBV is particularly important in pediatric oncology, as it is associated with Burkitt lymphoma, certain forms of Hodgkin lymphoma and nasopharyngeal carcinoma.
HBV, in turn, increases the risk of subsequent hepatocellular carcinoma in patients infected in childhood. The article analyzes the molecular mechanisms of oncogenic viruses, their association with childhood tumors, their epidemiological significance, the state of pediatric oncology worldwide and the importance of antiviral prevention.
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References
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