Homiladorlikda intragepatik xolestazning yuzaga kelishining patogenetik jihatlari

Pathogenetic aspects of the onset of intrahepatic cholestasis of pregnancy

Article Sidebar

PDF (Uzbek)
Published: 2026-10-30
DOI: https://doi.org/10.66073/ReFocus-Conf/3010127
Keywords:
intrahepatic cholestasis of pregnancy, bile acids, gut microbiota, bile salt hydrolase, FXR, pancreas, steatonecrosis

Main Article Content

Kenjayev Sherzod Ravshan ugli
Fergana Medical Institute of Public Health
Khoshimov Bobur Lukmanovich
Kimyo International University in Tashkent

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is a second- and third-trimester disorder of bile acid homeostasis hazardous to both mother and fetus. Archival material from 51 women who died of ICP complications between 2013 and 2023 and from 12 controls was examined morphologically, morphometrically and immunohistochemically. Congestive pancreatitis and steatonecrosis predominated in the pancreas. The findings implicate the deconjugating activity of the gut microbiota in ICP pathogenesis.

Article Details

Issue

Vol. 1 No. 8 (2026): Status and Development Prospects of Fundamental and Applied Microbiology: The Viewpoint of Young Scientists

Section

Infectious Diseases, Immunology and Laboratory Diagnostics
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Kenjayev Sherzod Ravshan ugli, & Khoshimov Bobur Lukmanovich. (2026). Pathogenetic aspects of the onset of intrahepatic cholestasis of pregnancy. Partner Conferences of the International Scientific Journal Research Focus, 1(8), 447-449. https://doi.org/10.66073/ReFocus-Conf/3010127

References

Ovadia C. [et al.] Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers // Lancet. – 2019. – Vol. 393. – P. 899–909. – DOI: 10.1016/S0140-6736(18)31877-4. DOI: https://doi.org/10.1016/S0140-6736(18)31877-4

Huang X. [et al.] Evaluating the influence of intrahepatic cholestasis of pregnancy on obstetric and neonatal outcomes // PLoS One. – 2024. – Vol. 19, № 6. – P. e0304604. – DOI: 10.1371/journal.pone.0304604. DOI: https://doi.org/10.1371/journal.pone.0304604

Ren S., Zhou Y., Xuan R. Role of gut microbiota and its metabolites in intrahepatic cholestasis of pregnancy // Expert Rev. Gastroenterol. Hepatol. – 2021. – Vol. 15, № 12. – P. 1361–1366. – DOI: 10.1080/17474124.2021.2011211. DOI: https://doi.org/10.1080/17474124.2021.2011211

Tang B. [et al.] Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy // Nat. Commun. – 2023. – Vol. 14. – P. 1305. – DOI: 10.1038/s41467-023-36981-4. DOI: https://doi.org/10.1038/s41467-023-36981-4

Zhan Q. [et al.] Alterations of the human gut microbiota in intrahepatic cholestasis of pregnancy // Front. Cell. Infect. Microbiol. – 2021. – Vol. 11. – P. 635680. – DOI: 10.3389/fcimb.2021.635680. DOI: https://doi.org/10.3389/fcimb.2021.635680

Lin Q.-X. [et al.] Intrahepatic cholestasis of pregnancy increases inflammatory susceptibility in neonatal offspring by modulating gut microbiota // Front. Immunol. – 2022. – Vol. 13. – P. 889646. – DOI: 10.3389/fimmu.2022.889646. DOI: https://doi.org/10.3389/fimmu.2022.889646

Ovadia C. [et al.] Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis // Lancet Gastroenterol. Hepatol. – 2021. – Vol. 6, № 7. – P. 547–558. – DOI: 10.1016/S2468-1253(21)00074-1. DOI: https://doi.org/10.1016/S2468-1253(21)00304-6