Siprofloksatsin asosidagi metall komplekslarining antibakterial faolligi va ularning çorvaçilikda nazariy-amaliy ahamiyati

Abstract

This article provides a comprehensive analysis of the theoretical foundations, chemical structure and membrane permeation mechanisms of the coordination compounds formed by the fluoroquinolone antibiotic ciprofloxacin with d-metal ions (Fe(III), Co(II), Mn(II), Cu(II), Bi(III)), which occupy an important place at the interface of modern chemistry and veterinary biotechnology, as well as their role in livestock practice. Theoretical studies show that the formation of chelate complexes with metal ions significantly increases the lipophilicity of the molecule through the delocalization of electron density between the ligand and the central atom and a decrease in the overall polarity of the molecule; this facilitates the passage of the substance through lipid layers and the bacterial cell wall by passive diffusion and, at the same time, restricts the activity of the efflux pumps by which bacteria expel drugs from the cell. The use of metal complexes in veterinary medicine is a promising direction for ensuring food safety by reducing the drug dose, decreasing adverse effects and eliminating the risk of antibiotic residue accumulation in livestock products (meat, milk, eggs).